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Coumadin for migraine headaches ). Triptans are more effective for children with low weight and for those with seizures. They have not been studied well for other children, especially infants. Coumadins have the potential to improve results of drugs for hypertension and atrial fibrillation. Coumadin and aspirin can be used together, or separately. This has not been studied. Coumadin does not appear to improve heart function in children with anemia. Preliminary studies cost of coumadin without insurance have not been done to determine whether Coumadin can help reduce the chances of stroke or increase the length of life. It is possible to overdose on Coumadine (as shown in clinical studies children) but this has not been seen in a large number of subjects over a long period (several to many years). The potential exists that Coumadin has more potential to affect brain development and function in children than adults. The effects of Coumadin on brain and behavior in children are unknown (see WARNINGS AND PRECAUTIONS). Coumadin and its metabolites are excreted in the urine. Some have been shown to biological activity in humans that could result neurotoxic effects in animals, especially animals given high doses. Dosing Maximum daily dose of Coumadin is 40 mg orally in children. The maximum daily dose of Coumadin for adults is 600 mg per day and for postmenopausal women is 200 mg per day. Oral administration: It is generally recommended that a single dose of Coumadin be taken with food. It is also recommended that a dose of 0.25 mg or 0.5 be given every 4 or 6 hours with meals; this dose must be repeated with food at meals to maintain clinical effectiveness; for children under 5 and infants (less than 30 days old) doses should be made every 8 to 12 hours with a dose interval of 4 to 8 hours between doses avoid sedation. If the patient is receiving other anticoagulants, Coumadin should not be used with them (see CONTRAINDICATIONS). It is not possible to combine Coumadin with other anticoagulants or medications that are not anticoagulants (also known as thrombolytics). Coumadin should not be administered during pregnancy. Coumadin is available as 30 to 80 mg tablets. Oral administration of Coumadin must be begun at the rate of 0.4 mg per pound body weight 2 hours prior to the first dose. Follow each dose for 15 minutes. Oral doses not titrated by volume are likely to be insufficient achieve clinical efficacy. Patients receiving other anticoagulants should not be treated with Coumadin. Treatment any anticoagulant should not be begun while Coumadin is being administered. Coumadin tablets should be taken with food that is at least 1 hour prior to each dose and should be continued until the patient is well. For children taking Coumadin as part of intravenous therapy, the dose (including duration of therapy, the length and frequency number of injections) should be individually adjusted if the patient has received more than two doses of Coumadin during the preceding 2 weeks. following medications can interfere with Coumadin administration: Heparin sodium (for hemophilia patients) or warfarin sodium. Coumadin, a protease inhibitor - for these patients, Coumadin must be taken in a higher rate. Nonsteroidal anti-inflammatory drugs (NSAIDS) (for example, ibuprofen or naproxen, diclofenac and aspirin). Antidiarrheals (for example, chlorpropamide, propacetamol). Stimulants (for example, cocaine, amphetamine, methylphenidate). Drugs that prolong the action of Coumadin or depress the central nervous system. Oral Contraceptives: Women who are taking Coumadin or an other anticoagulant (such as aspirin) to reduce the effects of pregnancy, and taking Coumadin for other medical indications are discouraged from using oral contraceptive pills while these therapies. The effects of Coumadin should not be expected on other hormonal contraceptives (OCs). Pregnancy Teratogenic Effects: In postmarketing trials, there was a higher incidence of congenital malformations the limbs in children compared to infants given Coumadin. Studies in adult subjects using Coumadin (for the treatment of asthma) and an OTC anticoagulant (for the treatment of effects ischemic stroke).
